Format

Send to

Choose Destination
Open Rheumatol J. 2012;6:232-44. doi: 10.2174/1874312901206010232. Epub 2012 Sep 7.

JAK Kinases in Health and Disease: An Update.

Author information

1
Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

Abstract

Janus kinases (Jaks) are critical signaling elements for a large subset of cytokines. As a consequence they play pivotal roles in the patho-physiology of many diseases including neoplastic and autoimmune diseases. Small molecule Jak inhibitors as therapeutic agents have become a reality and the palette of such inhibitors will likely expand. This review will summarize our current knowledge on these key enzymes and their associated pharmaceutical inhibitors.

KEYWORDS:

Jak; autoimunity; cancer; cytokine signaling.; kinase inhibitors; myelofibrosis; tyrosine kinase

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center