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Open Rheumatol J. 2012;6:232-44. doi: 10.2174/1874312901206010232. Epub 2012 Sep 7.

JAK Kinases in Health and Disease: An Update.

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Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.


Janus kinases (Jaks) are critical signaling elements for a large subset of cytokines. As a consequence they play pivotal roles in the patho-physiology of many diseases including neoplastic and autoimmune diseases. Small molecule Jak inhibitors as therapeutic agents have become a reality and the palette of such inhibitors will likely expand. This review will summarize our current knowledge on these key enzymes and their associated pharmaceutical inhibitors.


Jak; autoimunity; cancer; cytokine signaling.; kinase inhibitors; myelofibrosis; tyrosine kinase

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