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Vasc Health Risk Manag. 2012;8:533-9. doi: 10.2147/VHRM.S28041. Epub 2012 Sep 13.

The complex regulation of TGF-β in cardiovascular disease.

Author information

1
Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain. santiredondo@hotmail.com

Abstract

Transforming growth factor β (TGF-β1) is a pleiotropic cytokine with many and complex effects in cell and tissue physiology. This is made possible by a very complex and interwoven signaling system, whose regulation continues to be the focus of a growing line of research. This complex regulation translates to a key role in cardiovascular physiology, hemostasis, and the blood-vessel interface. In accordance with this, the TGF-β1 pathway appears to be deregulated in related disorders, such as atherosclerotic vascular disease and myeloproliferative syndromes. It is expected that the growing amount of experimental and clinical research will yield medical advances in the applications of knowledge of the TGF-β1 pathway to diagnosis and therapeutics.

KEYWORDS:

Smads; atherosclerosis; myeloproliferative syndromes; non-Smads; pathway; transforming growth factor beta

PMID:
23028232
PMCID:
PMC3446857
DOI:
10.2147/VHRM.S28041
[Indexed for MEDLINE]
Free PMC Article

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