Format

Send to

Choose Destination
Cold Spring Harb Perspect Med. 2012 Oct 1;2(10). pii: a006296. doi: 10.1101/cshperspect.a006296.

The genetics of Alzheimer disease.

Author information

1
Genetics and Aging Research Unit, Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129, USA. tanzi@helix.mgh.harvard.edu

Abstract

Family history is the second strongest risk factor for Alzheimer disease (AD) following advanced age. Twin and family studies indicate that genetic factors are estimated to play a role in at least 80% of AD cases. The inheritance of AD exhibits a dichotomous pattern. On one hand, rare mutations in APP, PSEN1, and PSEN2 virtually guarantee early-onset (<60 years) familial AD, which represents ∼5% of AD. On the other hand, common gene polymorphisms, such as the ε4 and ε2 variants of the APOE gene, can influence susceptibility for ∼50% of the common late-onset AD. These four genes account for 30%-50% of the inheritability of AD. Genome-wide association studies have recently led to the identification of 11 additional AD candidate genes. This paper reviews the past, present, and future attempts to elucidate the complex and heterogeneous genetic underpinnings of AD.

PMID:
23028126
PMCID:
PMC3475404
DOI:
10.1101/cshperspect.a006296
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Loading ...
Support Center