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J Cell Biol. 2012 Oct 1;199(1):9-13. doi: 10.1083/jcb.201207072.

Progeria: translational insights from cell biology.

Author information

1
The Progeria Research Foundation, Peabody, MA 01961, USA.

Abstract

Cell biologists love to think outside the box, pursuing many surprising twists and unexpected turns in their quest to unravel the mysteries of how cells work. But can cell biologists think outside the bench? We are certain that they can, and clearly some already do. To encourage more cell biologists to venture into the realm of translational research on a regular basis, we would like to share a handful of the many lessons that we have learned in our effort to develop experimental treatments for Hutchinson-Gilford progeria syndrome (HGPS), an endeavor that many view as a "poster child" for how basic cell biology can be translated to the clinic.

PMID:
23027899
PMCID:
PMC3461511
DOI:
10.1083/jcb.201207072
[Indexed for MEDLINE]
Free PMC Article

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