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Physiology (Bethesda). 2012 Oct;27(5):282-90. doi: 10.1152/physiol.00006.2012.

Insight into DEG/ENaC channel gating from genetics and structure.

Author information

1
Department of Molecular and Cellular Physiology, Stanford University, Stanford, California, USA. aeastwood@stanford.edu

Abstract

The founding members of the superfamily of DEG/ENaC ion channel proteins are C. elegans proteins that form mechanosensitive channels in touch and pain receptors. For more than a decade, the research community has used mutagenesis to identify motifs that regulate gating. This review integrates insight derived from unbiased in vivo mutagenesis screens with recent crystal structures to develop new models for activation of mechanically gated DEGs.

PMID:
23026751
PMCID:
PMC4012085
DOI:
10.1152/physiol.00006.2012
[Indexed for MEDLINE]
Free PMC Article

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