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J Nat Prod. 2012 Oct 26;75(10):1806-9. doi: 10.1021/np300380t. Epub 2012 Oct 1.

Antibiotic and antimalarial quinones from fungus-growing ant-associated Pseudonocardia sp.

Author information

1
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Abstract

Three new members of the angucycline class of antibiotics, pseudonocardones A-C (1-3), along with the known antibiotics 6-deoxy-8-O-methylrabelomycin (4) and X-14881 E (5) have been isolated from the culture of a Pseudonocardia strain associated with the fungus-growing ant Apterostigma dentigerum. Compounds 4 and 5 showed antibiotic activity against Bacillus subtilis 3610 and liver-stage Plasmodium berghei, while 1-3 were inactive or only weakly active in a variety of biological assays. Compound 5 also showed moderate cytotoxicity against HepG2 cells.

PMID:
23025282
PMCID:
PMC3481556
DOI:
10.1021/np300380t
[Indexed for MEDLINE]
Free PMC Article

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