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Microbiology. 2012 Dec;158(Pt 12):3014-9. doi: 10.1099/mic.0.061192-0. Epub 2012 Sep 28.

The catabolite repression control protein Crc plays a role in the development of antimicrobial-tolerant subpopulations in Pseudomonas aeruginosa biofilms.

Author information

1
China-Japan Union Hospital, Jilin University, Changchun, PR China.

Abstract

Bacteria form complex surface-attached biofilm communities in nature. Biofilm cells differentiate into subpopulations which display tolerance towards antimicrobial agents. However, the signal transduction pathways regulating subpopulation differentiation in biofilms are largely unelucidated. In the present study, we show that the catabolite repression control protein Crc regulates the metabolic state of Pseudomonas aeruginosa cells in biofilms, and plays an important role in the development of antimicrobial-tolerant subpopulations in P. aeruginosa biofilms.

PMID:
23023972
DOI:
10.1099/mic.0.061192-0
[Indexed for MEDLINE]

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