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Angew Chem Int Ed Engl. 2012 Oct 29;51(44):11122-5. doi: 10.1002/anie.201204169. Epub 2012 Sep 28.

Encapsulation of biomacromolecules within polymersomes by electroporation.

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1
The Krebs Institute, UK.

Abstract

Biological macromolecules can be encapsulated into preformed polymersomes by controlled temporary destabilization of the vesicle membrane. The morphology and the size of the polymersome are unchanged after electroporation, suggesting that the polymersome membrane is reformed. The surface charge of the biomacromolecules plays a key role for the electroporation process.

PMID:
23023772
DOI:
10.1002/anie.201204169
[Indexed for MEDLINE]

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