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J Clin Invest. 2012 Oct;122(10):3448-55. doi: 10.1172/JCI61205. Epub 2012 Oct 1.

New molecular insights into peripheral T cell lymphomas.

Author information

1
Hematopathology Section, Department of Hematology and Oncology L. and A. Seràgnoli, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy. stefano.pileri@unibo.it

Abstract

Peripheral T cell lymphomas (PTCLs) are heterogeneous neoplasms and represent about 12% of all lymphoid malignancies. They are often regarded as "orphan diseases," a designation that does not reflect their real incidence but rather signifies the difficulties encountered in their classification, diagnosis, and treatment. Here we revise the current understanding of the pathobiological characteristics of the most common nodal PTCLs by focusing on the contribution given by high-throughput technologies and the identification of potential therapeutic targets proposed by translational studies.

PMID:
23023716
PMCID:
PMC3461903
DOI:
10.1172/JCI61205
[Indexed for MEDLINE]
Free PMC Article
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