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J Clin Invest. 2012 Oct;122(10):3398-406. doi: 10.1172/JCI61269. Epub 2012 Oct 1.

The molecular basis of T cell acute lymphoblastic leukemia.

Author information

1
Institute for Cancer Genetics, Department of Pathology, Columbia University Medical Center, New York, New York 10032, USA.

Abstract

T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and genetic alterations in transcription factors, signaling oncogenes, and tumor suppressors. Notably, these genetic alterations define distinct molecular groups of T-ALL with specific gene expression signatures and clinicobiological features. This review summarizes recent advances in our understanding of the molecular genetics of T-ALL.

PMID:
23023710
PMCID:
PMC3461904
DOI:
10.1172/JCI61269
[Indexed for MEDLINE]
Free PMC Article

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