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FEBS Lett. 2012 Nov 2;586(21):3771-7. doi: 10.1016/j.febslet.2012.09.026. Epub 2012 Sep 26.

Role of poly(ADP-ribose) polymerases in the regulation of inflammatory processes.

Author information

1
Department of Medical Chemistry, Medical and Health Science Center, University of Debrecen, Debrecen H-4032, Hungary. baip@med.unideb.hu

Abstract

PARP enzymes influence the immune system at several key points and thus modulate inflammatory diseases. PARP enzymes affect immune cell maturation and differentiation and regulate the expression of inflammatory mediators such as cytokines, chemokines, inducible nitric oxide synthase and adhesion molecules. Moreover, PARP enzymes are key regulators of cell death during inflammation-related oxidative and nitrosative stress. Here we provide an overview of the different inflammatory diseases regulated by PARP enzymes.

PMID:
23022557
DOI:
10.1016/j.febslet.2012.09.026
[Indexed for MEDLINE]
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