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Am J Pathol. 2012 Nov;181(5):1484-92. doi: 10.1016/j.ajpath.2012.08.010. Epub 2012 Sep 25.

Cerebral malaria: we have come a long way.

Author information

1
Division of Parasitology and Tropical Medicine, Department of Pathology, Albert Einstein College of Medicine, Bronx, New York, USA.

Abstract

Despite decades of research, cerebral malaria remains one of the most serious complications of Plasmodium infection and is a significant burden in Sub-Saharan Africa, where, despite effective antiparasitic treatment, survivors develop long-term neurological sequelae. Although much remains to be discovered about the pathogenesis of cerebral malaria, The American Journal of Pathology has been seminal in presenting original research from both human and experimental models. These studies have afforded significant insight into the mechanism of cerebral damage in this devastating disease. The present review highlights information gleaned from these studies, especially in terms of their contributions to the understanding of cerebral malaria.

PMID:
23021981
PMCID:
PMC3483536
DOI:
10.1016/j.ajpath.2012.08.010
[Indexed for MEDLINE]
Free PMC Article

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