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Rev Esp Cardiol (Engl Ed). 2012 Dec;65(12):1086-93. doi: 10.1016/j.recesp.2012.04.026. Epub 2012 Sep 28.

Carotid intima-media thickness in the Spanish population: reference ranges and association with cardiovascular risk factors.

[Article in English, Spanish]

Author information

  • 1Grup d'Epidemiologia i Genètica Cardiovascular, Programa de Recerca en Processos Inflammatoris i Cardiovasculars, IMIM-Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, España. mgrau@imim.es

Abstract

INTRODUCTION AND OBJECTIVES:

Carotid intima-media thickness as measured with ultrasonography is an inexpensive and noninvasive predictor of cardiovascular events. The objectives of this study were to determine the population reference ranges of carotid intima-media thickness for individuals aged 35-84 years in Spain and to analyze the association of carotid intima-media thickness with cardiovascular risk factors (age, smoking, diabetes, pulse pressure, lipid profile, and body mass index).

METHODS:

Population-based cross-sectional study conducted in Gerona (Spain). We described the mean and maximal values of carotid intima-media thickness of the carotid artery and of its 3 segments (common carotid, carotid bulb and internal carotid). We assessed cardiovascular risk factors and analyzed their association with carotid intima-media thickness using adjusted linear regression models.

RESULTS:

A total of 3161 individuals (54% women) were included, with mean age 58 years. Men showed significantly higher mean common carotid intima-media thickness than did women (0.71 vs 0.67 mm). The strongest predictors of this measure were age (coefficients for 10-year increase: 0.65 and 0.58 for women and men, respectively), smoking in men (coefficient: 0.26), high-density lipoprotein cholesterol in women (coefficient for 10 mg/dL, increase: -0.08) and pulse pressure in both sexes (coefficients for 10 mmHg increase: 0.08 and 0.23 for women and men, respectively). The results were similar for the mean carotid intima-media thickness of all the segments.

CONCLUSIONS:

This population-based study presents the reference ranges for carotid intima-media thickness in the Spanish population. The main determinants of carotid intima-media thickness were age and pulse pressure in both sexes.

PMID:
23021836
DOI:
10.1016/j.recesp.2012.04.026
[PubMed - indexed for MEDLINE]
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