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J Genet Genomics. 2012 Sep 20;39(9):443-9. doi: 10.1016/j.jgg.2012.07.005. Epub 2012 Aug 11.

Overlapping cardiac programs in heart development and regeneration.

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1
Institute of Molecular Medicine, Peking University, Beijing, China.

Abstract

Gaining cellular and molecular insights into heart development and regeneration will likely provide new therapeutic targets and opportunities for cardiac regenerative medicine, one of the most urgent clinical needs for heart failure. Here we present a review on zebrafish heart development and regeneration, with a particular focus on early cardiac progenitor development and their contribution to building embryonic heart, as well as cellular and molecular programs in adult zebrafish heart regeneration. We attempt to emphasize that the signaling pathways shaping cardiac progenitors in heart development may also be redeployed during the progress of adult heart regeneration. A brief perspective highlights several important and promising research areas in this exciting field.

PMID:
23021544
DOI:
10.1016/j.jgg.2012.07.005
[Indexed for MEDLINE]

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