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J Neuroimmunol. 2013 Jan 15;254(1-2):19-27. doi: 10.1016/j.jneuroim.2012.08.014. Epub 2012 Sep 27.

Chronic social stress impairs virus specific adaptive immunity during acute Theiler's virus infection.

Author information

1
Department of Psychology, College of Liberal Arts, Texas A&M University, College Station, TX 77843, United States. youngee@pitt.edu

Abstract

Prior exposure to social disruption (SDR) stress exacerbates Theiler's murine encephalomyelitis virus (TMEV) infection, a model of multiple sclerosis. Here we examined the impact of SDR on T cell responses to TMEV infection in SJL mice. SDR impaired viral clearance and exacerbated acute disease. Moreover, TMEV infection alone increased CD4 and CD8 mRNA expression in brain and spleen while SDR impaired this response. SDR decreased both CD4(+) and CD8(+) virus-specific T cells in CNS, but not spleen. These findings suggest that SDR-induced suppression of virus-specific T cell responses contributes to impairments in viral clearance and exacerbation of acute disease.

PMID:
23021485
PMCID:
PMC4464662
DOI:
10.1016/j.jneuroim.2012.08.014
[Indexed for MEDLINE]
Free PMC Article
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