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Placenta. 2012 Nov;33(11):914-8. doi: 10.1016/j.placenta.2012.08.005. Epub 2012 Sep 25.

Stereological assessment of placental morphology in intrahepatic cholestasis of pregnancy.

Author information

1
Department of Obstetrics and Gynaecology, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden. elisabeth@gynocular.com

Abstract

OBJECTIVE:

To apply stereology for the detection of possibly morphological abnormalities in placentas of women with intrahepatic cholestasis of pregnancy (ICP).

STUDY DESIGN:

Prospective case-control study of placentas from untreated and UDCA-treated ICP, respectively, and normal pregnancies, examined for morphological differences by systematic random sampling generated by computerized stereology methodology.

MAIN OUTCOME MEASURES:

Volume of placenta, surface area of terminal villi and capillaries, volume fraction of collagen, number of syncytial knots, and chorangiosis.

RESULTS:

Surface area of terminal villi and capillaries, and number of syncytial knots were higher in placentas from all ICP, as compared to controls (p < 0.01). A reduction of collagen was found in placentas from UDCA-treated ICP, both in comparison to placentas from untreated ICP and controls (p < 0.05).

CONCLUSION:

ICP affects the placenta morphologically as shown by increased terminal villous and capillary surface area, and number of syncytial knots.

PMID:
23020907
DOI:
10.1016/j.placenta.2012.08.005
[Indexed for MEDLINE]
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