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Mol Cell. 2012 Sep 28;47(6):825-6. doi: 10.1016/j.molcel.2012.09.007.

RNase E finds some sRNAs stimulating.

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Laboratory of Molecular Biology, National Cancer Institute, Bethesda, MD 20892, USA.


In this issue of Molecular Cell, Bandyra et al. (2012) describe how a bacterial sRNA can lead to degradation of an mRNA by pairing within the coding region of the mRNA; the 5' monophosphate end of the sRNA activates RNase E, leading to rapid cleavage of the paired mRNA.

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