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Proc Natl Acad Sci U S A. 2012 Sep 25;109(39):15859-64. Epub 2012 Sep 10.

A mouse model for HIV-1 entry.

Author information

1
Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA.

Abstract

Passive transfer of neutralizing antibodies against HIV-1 can prevent infection in macaques and seems to delay HIV-1 rebound in humans. Anti-HIV antibodies are therefore of great interest for vaccine design. However, the basis for their in vivo activity has been difficult to evaluate systematically because of a paucity of small animal models for HIV infection. Here we report a genetically humanized mouse model that incorporates a luciferase reporter for rapid quantitation of HIV entry. An antibody's ability to block viral entry in this in vivo model is a function of its bioavailability, direct neutralizing activity, and effector functions.

PMID:
23019371
PMCID:
PMC3465400
DOI:
10.1073/pnas.1213409109
[Indexed for MEDLINE]
Free PMC Article

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