Format

Send to

Choose Destination
See comment in PubMed Commons below
Gut Microbes. 2013 Jan-Feb;4(1):48-53. doi: 10.4161/gmic.22328. Epub 2012 Sep 27.

Antimicrobials: Strategies for targeting obesity and metabolic health?

Author information

1
Alimentary Health Ltd., Cork, Ireland.

Abstract

Obesity is associated with a number of serious health consequences, including type 2 diabetes, cardiovascular disease and a variety of cancers among others and has been repeatedly shown to be associated with a higher risk of mortality. The relatively recent discovery that the composition and metabolic activity of the gut microbiota may affect the risk of developing obesity and related disorders has led to an explosion of interest in this distinct research field. A corollary of these findings would suggest that modulation of gut microbial populations can have beneficial effects with respect to controlling obesity. In this addendum, we summarize our recent data, showing that therapeutic manipulation of the microbiota using different antimicrobial strategies may be a useful approach for the management of obesity and metabolic conditions. In addition, we will explore some of the mechanisms that may contribute to microbiota-induced susceptibility to obesity and metabolic diseases.

KEYWORDS:

antimicrobials; firmicutes; gut microbiota; metabolic disease; obesity

PMID:
23018760
PMCID:
PMC3555886
DOI:
10.4161/gmic.22328
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Taylor & Francis Icon for PubMed Central
    Loading ...
    Support Center