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Food Chem. 2013 Jan 1;136(1):116-9. doi: 10.1016/j.foodchem.2012.07.094. Epub 2012 Aug 4.

Genistein and dicarboximide fungicides in infant formulae from the EU market.

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  • 1Mario Negri Institute for Pharmacological Research, Department of Environmental Health Sciences, Milan, Italy.


A method based on ultrasonic extraction and purification by solid phase extraction followed by LC-MS/MS and GC-MS analysis was developed for the determination of genistein, genistin, iprodione, vinclozolin and procymidone in infant powdered formulas. The method was tested for different formulations: milk, soy and hypoallergenic, and was applied to European pooled samples. Spike recoveries ranged from 53.1% to 91.5% and the relative standard deviation values for repeatability ranged from 9.6% to 17.7%, except for iprodione in milk formula (22.3%). None of the fungicides were found in the European pooled formulae, while genistein was found at 9.7μg/g in soy formula and the concentration of genistin, its β-glycosylated form, was respectively 31.4ng/g and 476ng/g in milk and soy formula.

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