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Immunol Invest. 2012;41(6-7):738-64. doi: 10.3109/08820139.2012.676122.

Indoleamine 2,3-dioxygenase and dendritic cell tolerogenicity.

Author information

1
The State University of New York at Buffalo, Buffalo, New York 14214, USA. jlharden@buffalo.edu

Abstract

This article summarizes the molecular and cellular mechanisms that regulate the activity of indoleamine 2,3-dioxygenase (IDO), a potent immune-suppressive enzyme, in dendritic cells (DCs). Specific attention is given to differential up-regulation of IDO in distinct DC subsets, its function in immune homeostasis/autoimmunity, infection and cancer; and the associated immunological outcomes. The review will conclude with a discussion of the poorly defined mechanisms that mediate the long-term maintenance of IDO-expression in response to inflammatory stimuli and how selective modulation of IDO activity may be used in the treatment of disease.

PMID:
23017144
PMCID:
PMC3645912
DOI:
10.3109/08820139.2012.676122
[Indexed for MEDLINE]
Free PMC Article

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