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Phytochemistry. 2013 Jan;85:137-42. doi: 10.1016/j.phytochem.2012.08.024. Epub 2012 Sep 24.

Gastroprotective effect and structure of a rhamnogalacturonan from Acmella oleracea.

Author information

1
Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Paraná, CEP 81.531-980, CP 19046, Curitiba, PR, Brazil.

Abstract

The plant Acmella oleracea (L.) R.K.Jansen (Asteraceae), locally known as jambu, is widely used in Legal Amazon in local dishes and in folk medicine. A polysaccharide (SC) was isolated from this plant, following aqueous extraction, which contained uronic acid, galactose, arabinose, rhamnose, and glucose in a 15:2:1:1:0.5 molar ratio and had a M(w) 226,000 g/mol. Methylation analysis and NMR spectroscopy indicated that SC is a rhamnogalacturonan composed of a long chain of →4)-6-OMe-α-D-GalpA-(1→, interspersed with some α-L-Rhap residues, partly substituted by side-chains of type II arabinogalactans. SC significantly inhibited ethanol-induced gastric ulcers in rats with an ED₅₀ of 1.5 mg/kg, indicating that SC acts as gastroprotective agent.

PMID:
23014505
DOI:
10.1016/j.phytochem.2012.08.024
[Indexed for MEDLINE]

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