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Genome Biol. 2012 Jul 5;13(9):R78. doi: 10.1186/gb-2012-13-9-r78.

RELATCH: relative optimality in metabolic networks explains robust metabolic and regulatory responses to perturbations.

Author information

1
Department of Chemical and Biological Engineering, University of Wisconsin-Madison, Madison, WI, USA.

Abstract

Predicting cellular responses to perturbations is an important task in systems biology. We report a new approach, RELATCH, which uses flux and gene expression data from a reference state to predict metabolic responses in a genetically or environmentally perturbed state. Using the concept of relative optimality, which considers relative flux changes from a reference state, we hypothesize a relative metabolic flux pattern is maintained from one state to another, and that cells adapt to perturbations using metabolic and regulatory reprogramming to preserve this relative flux pattern. This constraint-based approach will have broad utility where predictions of metabolic responses are needed.

PMID:
23013597
PMCID:
PMC3506949
DOI:
10.1186/gb-2012-13-9-r78
[Indexed for MEDLINE]
Free PMC Article

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