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Viruses. 2012 Aug;4(8):1182-201. Epub 2012 Aug 3.

Herpesvirus exploitation of host immune inhibitory pathways.

Author information

1
Institute of Infection and Immunity, Cardiff University, Cardiff, CF14 4XN, UK. stackg@cf.ac.uk

Abstract

Herpesviruses employ a plethora of mechanisms to circumvent clearance by host immune responses. A key feature of mammalian immune systems is the employment of regulatory pathways that limit immune responsiveness. The primary functions of these mechanisms are to control autoimmunity and limit exuberant responses to harmless antigen in mucosal surfaces. However, such pathways can be exploited by viral pathogens to enable acute infection, persistence and dissemination. Herein, we outline the current understanding of inhibitory pathways in modulating antiviral immunity during herpesvirus infections in vivo and discuss strategies employed by herpesviruses to exploit these pathways to limit host antiviral immunity.

KEYWORDS:

BTLA; CD200; IL-10; PD-1; cytomegalovirus; herpesvirus; immune suppression

PMID:
23012619
PMCID:
PMC3446756
DOI:
10.3390/v4081182
[Indexed for MEDLINE]
Free PMC Article
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