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Antivir Ther. 2013;18(2):141-7. doi: 10.3851/IMP2402. Epub 2012 Sep 25.

Silymarin for HCV infection.

Author information

1
Department of Laboratory Medicine, University of Washington, Seattle, WA, USA. polyak@uw.edu

Abstract

Silymarin, an extract of milk thistle seeds, and silymarin-derived compounds have been considered hepatoprotective since the plant was first described in ancient times. Hepatoprotection is defined as several non-mutually exclusive biological activities including antiviral, antioxidant, anti-inflammatory and immunomodulatory functions. Despite clear evidence for silymarin-induced hepatoprotection in cell culture and animal models, evidence for beneficial effects in humans has been equivocal. This review will summarize the current state of knowledge on silymarin in the context of HCV infection. The information was collated from a recent workshop on silibinin in Germany.

PMID:
23011959
PMCID:
PMC4076489
DOI:
10.3851/IMP2402
[Indexed for MEDLINE]
Free PMC Article
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