Format

Send to

Choose Destination
See comment in PubMed Commons below
Pediatr Infect Dis J. 2013 Feb;32(2):187-9. doi: 10.1097/INF.0b013e31827412fc.

Evaluation of an interferon-gamma release assay in children with suspected tuberculosis in Papua New Guinea.

Author information

1
Division of Child Health, Port Moresby General Hospital and School of Medicine and Health Sciences, University of Papua New Guinea, Port Moresby, Papua New Guinea.

Abstract

There are few data from tuberculosis (TB) endemic settings of the performance and outcome predictors of the QuantiFERON-TB Gold in Tube assay (QFT) in children with suspected TB. A prospective cross-sectional study was conducted in Papua New Guinea children with suspected TB evaluated at Port Moresby General Hospital (Port Moresby, Papua New Guinea). Two hundred sixteen children were enrolled including 106 probable TB, 87 possible TB and 23 without TB. Concordance between QFT and tuberculin skin test results was 86% (P < 0.001, κ = 0.70). QFT was significantly more likely to be positive than tuberculin skin test, overall and within the probable or possible TB categories, with no difference in prevalence of positivity between these 2 categories. The role of QFT in supporting the clinical diagnosis of TB in endemic settings, where resources are limited, remains uncertain especially as cost and technical requirements remain considerable.

PMID:
23011011
DOI:
10.1097/INF.0b013e31827412fc
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Support Center