Format

Send to

Choose Destination
Cancer Lett. 2013 Jun 28;334(1):39-45. doi: 10.1016/j.canlet.2012.09.010. Epub 2012 Sep 23.

DNA methylome alterations in chemical carcinogenesis.

Author information

1
Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA. Electronic address: igor.pogribny@fda.hhs.gov.
2
Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR 72079, USA. Electronic address: frederick.beland@fda.hhs.gov.

Abstract

Carcinogenesis, a complex multifactorial process of the transformation of normal cells into malignant cells, is characterized by many biologically significant and interdependent alterations triggered by the mutational and/or non-mutational (i.e., epigenetic) events. One of these events, specific to all types of cancer, is alterations in DNA methylation. This review summarizes the current knowledge of the role of DNA methylation changes induced by various genotoxic chemicals (carcinogenic agents that interact with DNA) and non-genotoxic carcinogens (chemicals causing tumor by mechanisms other than directly damaging DNA) in the lung, colorectal, liver, and hematologic carcinogenesis. It also emphasizes the potential role for epigenetic changes to serve as markers for carcinogen exposure and carcinogen risk assessment.

PMID:
23010082
DOI:
10.1016/j.canlet.2012.09.010
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center