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Hematol Oncol Clin North Am. 2012 Oct;26(5):1065-81. doi: 10.1016/j.hoc.2012.07.007. Epub 2012 Aug 21.

Myeloproliferative neoplasm animal models.

Author information

1
Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Abstract

Myeloproliferative neoplasm (MPN) animal models accurately re-capitulate human disease in mice and have been an important tool for the study of MPN biology and therapy. Transplantation of BCR-ABL transduced bone marrow into irradiated syngeneic mice established the field of MPN animal modeling. Genetically engineered MPN animal models have enabled detailed characterization of the effects of specific MPN-associated genetic abnormalities on hematopoietic stem and progenitor cells (HSPCs). Xenograft models have allowed the study of primary human MPN-propagating cells in vivo. JAK2V617F, the most common molecular abnormality in BCR-ABL negative MPN, has been extensively studied using retroviral, transgenic, knock-in and xenograft models.

PMID:
23009938
PMCID:
PMC3459181
DOI:
10.1016/j.hoc.2012.07.007
[Indexed for MEDLINE]
Free PMC Article

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