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Gene. 2012 Nov 15;510(1):59-65. doi: 10.1016/j.gene.2012.08.021. Epub 2012 Aug 23.

Impact of cytokine and cytokine receptor gene polymorphisms on cellular immunity after smallpox vaccination.

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1
Mayo Clinic Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA.

Abstract

We explored associations between SNPs in cytokine/cytokine receptor genes and cellular immunity in subjects following primary smallpox vaccination. We also analyzed the genotype-phenotype associations discovered in the Caucasian subjects among a cohort of African-Americans. In Caucasians we found 277 associations (p<0.05) between gene SNPs and inter-individual variations in IFN-α, IL-12p40, IL-1β, IL-2, and TNF-α secretion levels. A collection of SNPs in the IL1RN, IL2RB, IL4R, IL6, IL10RB, IL12A, and IL12RB2 genes had consistent associations among both Caucasians and African-Americans. A regulatory SNP (rs452204) in the IL1RN gene was significantly associated with higher levels of IL-2 secretion in an allele dose-dependent manner in both race groups (p=0.05 for Caucasians and p=0.002 for African-Americans). IL12RB2 polymorphism rs3790567 was associated with a dose-related decrease in IL-1β secretion (p=0.009 for Caucasians and p=0.01 for African-Americans). Our results demonstrate that variations in smallpox vaccine-induced cytokine responses are modulated by genetic polymorphisms in cytokine and cytokine receptor genes.

PMID:
23009887
PMCID:
PMC3463724
DOI:
10.1016/j.gene.2012.08.021
[Indexed for MEDLINE]
Free PMC Article
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