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Clin Genet. 2013 Jul;84(1):74-7. doi: 10.1111/cge.12026. Epub 2012 Oct 17.

Fragile X-associated tremor/ataxia syndrome (FXTAS) in grey zone carriers.

Author information

1
Department of Neurology, Dalian Municipal Friendship Hospital, Dalian, PR China.

Abstract

The grey zone (GZ; 45-54 CGG repeats in the FMR1 gene) is considered a normal allele; however, several studies have found a high frequency of GZ in movement disordered populations. Here, we describe neurological features of fragile X-associated tremor/ataxia syndrome (FXTAS) in two carriers of GZ alleles, although FXTAS has been defined as occurring only in premutation carriers (55-200 CGG repeats). Both patients had family members who had premutation and were diagnosed with FXTAS. The presence of relatively high GZ alleles with elevated fragile X mental retardation 1 mRNA (FMR1-mRNA) combined with a family history of FXTAS that may represent a facilitating genetic background for FXTAS are the factors that led to the presence of FXTAS in these individuals with a GZ allele. Further research into clinical involvement of GZ alleles is recommended and the definition of FXTAS may require revision.

PMID:
23009394
PMCID:
PMC4991824
DOI:
10.1111/cge.12026
[Indexed for MEDLINE]
Free PMC Article

Conflict of interest statement

There are no other conflicts of interest from the authors.

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