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Cell Mol Life Sci. 2013 Jul;70(13):2259-69. doi: 10.1007/s00018-012-1162-7. Epub 2012 Sep 25.

Robustness of signal transduction pathways.

Author information

1
Institute of Pathology, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany. nils.bluethgen@charite.de

Abstract

Signal transduction pathways transduce information about the outside of the cell to the nucleus, regulating gene expression and cell fate. To reliably inform the cell about its surroundings, information transfer has to be robust against typical perturbation that a cell experiences. Robustness of several mammalian signaling pathways has been studied recently by quantitative experimentation and using mathematical modeling. Here, we review these studies, and describe the emerging concepts of robustness and the underlying mechanisms.

PMID:
23007845
DOI:
10.1007/s00018-012-1162-7
[Indexed for MEDLINE]

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