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Nat Rev Immunol. 2012 Oct;12(10):696-708. doi: 10.1038/nri3299.

Dietary influences on intestinal immunity.

Author information

1
Laboratory for Lymphocyte Signalling and Development, The Babraham Institute, Cambridge, CB22 3AT, UK. marc.veldhoen@babraham.ac.uk

Abstract

The function of the gastrointestinal tract relies on a monolayer of epithelial cells, which are essential for the uptake of nutrients. The fragile lining requires protection against insults by a diverse array of antigens. This is accomplished by the mucosa-associated lymphoid tissues of the gastrointestinal tract, which constitute a highly organized immune organ. In this Review, we discuss several recent findings that provide a compelling link between dietary compounds and the organization and maintenance of immune tissues and lymphocytes in the intestine. We highlight some of the molecular players involved, in particular ligand-activated nuclear receptors in lymphoid cells.

PMID:
23007570
DOI:
10.1038/nri3299
[Indexed for MEDLINE]

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