Format

Send to

Choose Destination
See comment in PubMed Commons below
Arch Toxicol. 2013 Feb;87(2):227-47. doi: 10.1007/s00204-012-0931-2. Epub 2012 Sep 25.

Cellular and molecular mechanisms of hepatocellular carcinoma: an update.

Author information

1
Department of Radiology, University of Minnesota Medical School, Minneapolis, MN 55455, USA. arava001@umn.edu

Abstract

Hepatocellular carcinoma (HCC) is the most common primary malignant tumor that accounts for ~80 % of all liver cancer cases worldwide. It is a multifactorial disease caused by a variety of risk factors and often develops in the background of underlying cirrhosis. A number of cellular phenomena, such as tumor microenvironment, inflammation, oxidative stress, and hypoxia act in concert with various molecular events to facilitate tumor initiation, progression, and metastasis. The emergence of microRNAs and molecular-targeted therapies adds a new dimension in our efforts to combat this deadly disease. Intense research in this multitude of areas has led to significant progress in our understanding of cellular processes and molecular mechanisms that occur during multistage events that lead to hepatocarcinogenesis. In this review, we discuss the current knowledge of HCC, focusing mainly on advances that have occurred during the past 5 years and on the development of novel therapeutics for liver cancer.

PMID:
23007558
DOI:
10.1007/s00204-012-0931-2
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center