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Phys Rev Lett. 2012 Jul 27;109(4):048101. Epub 2012 Jul 23.

Pathway-based mean-field model for Escherichia coli chemotaxis.

Author information

1
The State Key Laboratory for Artificial Microstructures and Mesoscopic Physics, School of Physics, Peking University, Beijing 100871, China.

Abstract

We develop a mean-field theory for Escherichia coli chemotaxis based on the coupled spatiotemporal dynamics of the cell population and the mean receptor methylation level field. This multiscale model connects the cells' population level motility behavior with the molecular level pathway dynamics. It reveals a simple scaling dependence of the chemotaxis velocity on the adaptation rate in exponential gradients. It explains the molecular origin of a maximum chemotaxis velocity. Simulations of our model in various spatiotemporal stimuli profiles show quantitative agreements with experiments. Moreover, it predicts a surprising reversal of chemotaxis group velocity in traveling wave environments. Our approach may be used to bridge molecular level pathway dynamics with cellular behavior in other biological systems.

PMID:
23006109
PMCID:
PMC3458579
DOI:
10.1103/PhysRevLett.109.048101
[Indexed for MEDLINE]
Free PMC Article
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