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Phys Rev Lett. 2012 Sep 14;109(11):118102. Epub 2012 Sep 12.

General theory of genotype to phenotype mapping: derivation of epigenetic landscapes from N-node complex gene regulatory networks.

Author information

1
Instituto de Física, Universidad Nacional Autónoma de México, D.F. México, Mexico.

Abstract

We propose a systematic methodology to construct a probabilistic epigenetic landscape of cell-fate attainment associated with N-node Boolean genetic regulatory networks. The general derivation proposed here is exemplified with an Arabidopsis thaliana network underlying floral organ determination grounded on qualitative experimental data.

PMID:
23005679
DOI:
10.1103/PhysRevLett.109.118102
[Indexed for MEDLINE]

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