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Phys Rev E Stat Nonlin Soft Matter Phys. 2012 Jul;86(1 Pt 1):010106. Epub 2012 Jul 30.

Noise-induced metastability in biochemical networks.

Author information

1
Theoretical Physics Division, School of Physics and Astronomy, University of Manchester, Manchester M13 9PL, United Kingdom.

Abstract

Intracellular biochemical reactions exhibit a rich dynamical phenomenology which cannot be explained within the framework of mean-field rate equations and additive noise. Here, we show that the presence of metastable states and radically different time scales are general features of a broad class of autocatalytic reaction networks, and that this fact may be exploited to gain analytical results. The latter point is demonstrated by a treatment of the paradigmatic Togashi-Kaneko reaction, which has resisted theoretical analysis for the last decade.

PMID:
23005355
DOI:
10.1103/PhysRevE.86.010106
[Indexed for MEDLINE]

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