Format

Send to

Choose Destination
See comment in PubMed Commons below
Clin Transplant. 2013 Jan-Feb;27(1):162-7. doi: 10.1111/ctr.12023. Epub 2012 Sep 24.

Immediate renal transplantation after radical prostatectomy for low-risk prostate cancer.

Author information

1
Department of Urology, Massachusetts General Hospital, Boston, MA 02114, USA. ekreydin@partners.org

Abstract

INTRODUCTION:

For most cancers, a two- to five-yr period with no evidence of disease must be demonstrated before organ transplantation. The natural history of prostate cancer is unique both because of extensive pre-treatment screening and the ease of post-treatment monitoring for recurrence. Using available predictive models for prostate cancer recurrence, we examine whether current evidence supports a prolonged waiting period after radical prostatectomy and before renal transplantation.

MATERIALS AND METHODS:

A MedLine search was conducted to identify five series (published between 2000 and 2011), which examined biochemical recurrence (BCR) after prostatectomy for low-risk prostate cancer. The likelihood of BCR at one, two, and five yr after radical prostatectomy was identified for each series.

RESULTS:

Each of the analyzed series demonstrated that the likelihood of BCR after radical prostatectomy for low-risk prostate cancer was identical at one, two, and five yr and did not exceed 5%.

CONCLUSIONS:

The likelihood of BCR does not increase during the first five yr after radical prostatectomy for low-risk prostate cancer. Additionally, the risk of recurrence approaches zero during this period. Therefore, current evidence does not support the mandated waiting period of five yr before organ transplantation.

PMID:
23004927
DOI:
10.1111/ctr.12023
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center