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Pediatr Dermatol. 2014 Mar-Apr;31(2):236-40. doi: 10.1111/j.1525-1470.2012.01856.x. Epub 2012 Sep 25.

Cutaneous leukocytoclastic vasculitis due to Salmonella enteritidis in a child with interleukin-12 receptor beta-1 deficiency.

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1
Department of Pediatric Allergy and Immunology, Akdeniz University School of Medicine, Antalya, TurkeyDepartment of Pediatric Hematology, Akdeniz University School of Medicine, Antalya, TurkeyDepartment of Pathology, Akdeniz University School of Medicine, Antalya, TurkeyDepartment of Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.

Abstract

Defects in the interleukin 12 (IL-12)/interferon gamma (IFN-γ) pathway result in Mendelian susceptibility to mycobacterial disease (MSMD). IL-12 receptor beta 1 (IL-12Rβ1) deficiency, the most common form of MSMD, is associated with weakly virulent mycobacteria and salmonella. Infections in patients with this deficiency are extraintestinal, or septicemic, recurrent infections with nontyphoid salmonellae. Here we report a case of an IL-12Rβ1 deficiency with cutaneous leukocytoclastic vasculitis due to Salmonella enteritidis.

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