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Biomacromolecules. 2012 Oct 8;13(10):3220-7. doi: 10.1021/bm3009999. Epub 2012 Sep 25.

Cyclam-based polymeric copper chelators for gene delivery and potential PET imaging.

Author information

1
Department of Pharmaceutical Sciences, Wayne State University, Detroit, MI, USA.

Abstract

A series of reducible polycationic copper chelators (RPCs) based on 1,4,8,11-tetraazacyclotetradecane (cyclam) were synthesized by Michael addition. Molecular weight of the polycations was controlled by reaction stoichiometry and reaction conditions, resulting in polymers with molecular weights ranging from 4400 to 13 800. The cyclam moieties in the polycations retained their ability to form complexes with Cu(II). The presence of disulfide bonds in the polycations resulted in substantially lower cytotoxicity than control 25 kDa poly(ethyleneimine). RPC as well as their complexes with Cu(II) exhibited high transfection activity in vitro. The reported polycationic Cu(II) chelates represent promising nucleic acid delivery vectors with potential for future theranostic applications.

PMID:
23004346
PMCID:
PMC4102145
DOI:
10.1021/bm3009999
[Indexed for MEDLINE]
Free PMC Article

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