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Fetal Pediatr Pathol. 2013 Jun;32(3):222-34. doi: 10.3109/15513815.2012.721477. Epub 2012 Sep 24.

Systemic inflammation associated with severe intestinal injury in extremely low gestational age newborns.

Author information

1
Department of Neonatology, Beth Israel Deaconess Medical Center, Boston, MA, USA. cmartin1@bidmc.harvard.edu

Abstract

To define the role of systemic inflammation in infants with intestinal perforation (IP) and necrotizing enterocolitis (NEC), we measured 25 blood protein concentrations on days 1, 7 and 14 in 939 infants born before 28 weeks' gestation. On days 7 and 14, infants with NEC had elevated levels of C-reactive protein (CRP), serum amyloid A (SAA), IL-6 and IL-8. Infants with IP had elevated levels of CRP and insulin growth factor binding protein-1 on day 7 and elevated CRP, SAA, TNF-receptor-2 and matrix metalloproteinase-9 levels on day 14. A better understanding of systemic inflammation might help prevent and treat these disorders.

PMID:
23002960
PMCID:
PMC4201234
DOI:
10.3109/15513815.2012.721477
[Indexed for MEDLINE]
Free PMC Article

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