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J Nat Prod. 2012 Oct 26;75(10):1712-6. doi: 10.1021/np300255r. Epub 2012 Sep 24.

Bioassay-guided investigation of the Tanzanian plant Pyrenacantha kaurabassana for potential anti-HIV-active compounds.

Author information

1
Molecular Sciences Institute, School of Chemistry, University of the Witwatersrand , P.O. Wits 2050, Johannesburg, South Africa.

Abstract

Two new anti-HIV xanthones, 6,7,11-trihydroxy-10-methoxy-9-(7-methoxy-3-methyl-1-oxoisochroman-5-yl)-2-methyl-12-oxo-12H-benzo[b]xanthene-4-carboxylic acid (1) and 6,7-dihydroxy-10,11-dimethoxy-9-(7-methoxy-3-methyl-1-oxoisochroman-5-yl)-2-methyl-12-oxo-12H-benzo[b]xanthene-4-carboxylic acid (2), and a new hexadecahydrochrysen-3-ol (3) were isolated from the tubers of Pyrenacantha kaurabassana. Compounds 1 and 2 showed moderate anti-HIV activity when tested in the deCIPhR assay on HIV virus type NL4-3, with IC₅₀ values of 21 and 2 μg/mL, respectively.

PMID:
23002902
DOI:
10.1021/np300255r
[Indexed for MEDLINE]

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