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World J Gastroenterol. 2012 Sep 14;18(34):4744-50.

Clinicopathologic significance of expression of nuclear factor-κB RelA and its target gene products in gastric cancer patients.

Author information

1
Department of Internal Medicine, Dong-A University College of Medicine, Busan 602-715, South Korea.

Abstract

AIM:

To assess the prognostic significance of nuclear factor-κB (NF-κB) and its target genes in gastric cancer.

METHODS:

The tumor tissues of 115 patients with gastric cancer were immunohistochemically evaluated using monoclonal antibodies against NF-κB RelA. Preoperative serum levels of vascular endothelial growth factor (VEGF), interleukin-6 (IL-6) were assessed via enzyme-linked immuno-sorbent assay. C-reactive protein (CRP) and serum amyloid A (SAA) were measured via immunotrubidimetry.

RESULTS:

Positive rate of NF-κB RelA was 42.6%. NF-κB RelA expression in tumor tissues was also related to serum levels of IL-6 (P = 0.044) and CRP (P = 0.010). IL-6, SAA, CRP were related to depth of invasion, VEGF and SAA were correlated with lymph node metastasis. IL-6, VEGF, SAA and CRP were related to the stage. Univariate analysis demonstrated that immunostaining of NF-κB RelA, levels of IL-6, VEGF, SAA were significantly related with both disease free survival and overall survival (OS). Multivariate analysis verified that NF-κB RelA [hazard ratio (HR): 3.40, P = 0.024] and SAA (HR: 3.39, P = 0.045) were independently associated with OS.

CONCLUSION:

Increased expression of NF-κB RelA and high levels of serum SAA were associated with poor OS in gastric cancer patients.

KEYWORDS:

C-reactive protein; Carcinoma; Interleukin-6; Nuclear factor-κB; Serum amyloid A; Stomach; Vascular endothelial growth factor

PMID:
23002344
PMCID:
PMC3442213
DOI:
10.3748/wjg.v18.i34.4744
[Indexed for MEDLINE]
Free PMC Article

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