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Nature. 1990 Feb 8;343(6258):531-5.

Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils.

Author information

1
Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.

Abstract

The macrophage scavenger receptor is a trimeric membrane glycoprotein with unusual ligand-binding properties which has been implicated in the development of atherosclerosis. The trimeric structure of the bovine type I scavenger receptor, deduced by complementary DNA cloning, contains three extracellular C-terminal cysteine-rich domains connected to the transmembrane domain by a long fibrous stalk. This stalk structure, composed of an alpha-helical coiled coil and a collagen-like triple helix, has not previously been observed in an integral membrane protein.

PMID:
2300204
DOI:
10.1038/343531a0
[Indexed for MEDLINE]

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