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Curr Allergy Asthma Rep. 2012 Dec;12(6):564-73. doi: 10.1007/s11882-012-0304-1.

The impact of dietary long-chain polyunsaturated fatty acids on respiratory illness in infants and children.

Author information

1
Human Nutrition Department, Wageningen University, Bornse Weilanden 9, 6708 WG, Wageningen, the Netherlands. jeske.hageman@gmail.com

Abstract

Increasing evidence suggests that intake of long-chain polyunsaturated fatty acids (LCPUFA), especially omega-3 LCPUFA, improves respiratory health early in life. This review summarizes publications from 2009 through July 2012 that evaluated effects of fish, fish oil or LCPUFA intake during pregnancy, lactation, and early postnatal years on allergic and infectious respiratory illnesses. Studies during pregnancy found inconsistent effects in offspring: two showed no effects and three showed protective effects of omega-3 LCPUFA on respiratory illnesses or atopic dermatitis. Two studies found that infants fed breast milk with higher omega-3 LCPUFA had reduced allergic manifestations. Earlier introduction of fish improved respiratory health or reduced allergy in four studies. Three randomized controlled trials showed that providing LCPUFA during infancy or childhood reduced allergy and/or respiratory illness while one found no effect. Potential explanations for the variability among studies and possible mechanisms of action for LCPUFA in allergy and respiratory disease are discussed.

PMID:
23001718
PMCID:
PMC3492691
DOI:
10.1007/s11882-012-0304-1
[Indexed for MEDLINE]
Free PMC Article

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