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Diabetologia. 2012 Dec;55(12):3152-4. doi: 10.1007/s00125-012-2727-6. Epub 2012 Sep 22.

Islet nerves in focus--defining their neurobiological and clinical role.

Author information

1
Department of Clinical Sciences, Lund University, Lund, Sweden. Bo.Ahren@med.lu.se

Abstract

Although it is well established that the pancreatic islets are innervated by autonomic nerves, the detailed islet innervation pattern is still unclear. In this issue of Diabetologia (DOI: 10.1007/s00125-012-2699-6 ) novel details of the islet neuroanatomy and its plasticity in experimental diabetes are described. By using a 3-dimensional (3-D) imaging technique, it has been shown that, in islets from normal mice, sympathetic nerves mainly form a neurovascular complex in addition to innervating peripherally located islet alpha cells. There are also pronounced changes in islet neuroanatomy in experimental diabetes. These findings suggest novel neural-islet regulatory mechanisms as well as neural involvement in the development of diabetes, and therefore advance both basic and clinical knowledge of islet neurobiology.

PMID:
23001378
DOI:
10.1007/s00125-012-2727-6
[Indexed for MEDLINE]

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