The BCa raSNP rs4784227 affects cell proliferation by disrupting TOX3 gene expression. (a) Ratio between variant and reference alleles for DNA and RNA levels of each SNP (rs2193094 in TOX3; rs35925303 in CHD9; rs11646260 in FTO). (b) Cell line-based e-QTL results for the SNP rs4784227 and expression level of the gene TOX3 (rs4784227: T47D, T/T; HCC1428, C/T; MCF7, C/T; MDA-MB-415, C/T; UACC-812, C/C; ZR-75-1, C/C; BT-474, C/C; BT-483, C/C; MDA-MB-175VII, C/C; 600MPE, C/C; ZR-75-30, C/C). (c) TOX3 silencing in ZR75-1 cells. (d) The number of cells counted 2 days after TOX3 silencing. N.S., not significant; *, p≤0.05; **, p≤0.01; ***, p≤0.001. Error bars, SEM from three replicate measures.