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Nat Genet. 2012 Nov;44(11):1182-4. doi: 10.1038/ng.2417. Epub 2012 Sep 23.

Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk.

Author information

1
The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK. nicholas.orr@icr.ac.uk

Abstract

We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 × 10(-13); odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 × 10(-15); OR = 1.50).

PMID:
23001122
PMCID:
PMC3722904
DOI:
10.1038/ng.2417
[Indexed for MEDLINE]
Free PMC Article

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