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Exerc Sport Sci Rev. 2012 Oct;40(4):188-94.

Effect of statins on skeletal muscle: exercise, myopathy, and muscle outcomes.

Author information

1
Division of Cardiology, Henry Low Heart Center, Hartford Hospital, Hartford, CT 06012, USA. bparker03@harthosp.org

Erratum in

  • Exerc Sport Sci Rev. 2013 Jan;41(1):71.

Abstract

Statins are effective in reducing low-density lipoprotein cholesterol and cardiac events but can produce muscle side effects. We have hypothesized that statin-related muscle complaints are exacerbated by exercise and influenced by factors including mitochondrial dysfunction, membrane disruption, and/or calcium handling. The interaction between statins, exercise, and muscle symptoms may be more effectively diagnosed and treated as rigorous scientific studies accumulate.

Comment in

PMID:
23000957
PMCID:
PMC3463373
DOI:
10.1097/JES.0b013e31826c169e
[Indexed for MEDLINE]
Free PMC Article

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