Format

Send to

Choose Destination
Int J Biol Macromol. 2013 Jan;52:66-71. doi: 10.1016/j.ijbiomac.2012.09.009. Epub 2012 Sep 19.

Evaluation of in vivo antioxidant activity of Hericium erinaceus polysaccharides.

Author information

1
Department of Urology, Luqiao Hospital of Taizhou Enze Medical Center (Group), Taizhou, Zhejiang Province 318050, PR China.

Abstract

Hericium erinaceus polysaccharide (HEP) is a traditional Chinese medicine. In the present study, chemical composition and antioxidant activity of HEP was investigated. HPLC analysis showed that the HEP was composed of xylose (7.8%), ribose (2.7%), glucose (68.4%), arabinose (11.3%), galactose (2.5%) and mannose (5.2%). HEP was pre-administered to mice by gavage at a dose of 300 mg/kg for 15 days. Results found that HEP preadministration resulted in a significant decline in blood urea nitrogen (BUN), serum creatinine (Scr) and increase in creatinine clearance (CrCI) levels in HEP-pretreated group compared to renal ischemia reperfusion (IR) group. Malondialdehyde (MDA) level significantly increased, whereas Level of reduced glutathione (GSH) markedly decreased in renal IR animals. These results indicate that IR induced renal oxidative injury damage, as indicated by a increase in MDA level, and decrease in GSH level as well as the antioxidant enzymes activity. Such effects reflect that HEP can significantly decrease lipid peroxidation level and increase antioxidant enzymes activities in experimental animals.

PMID:
23000690
DOI:
10.1016/j.ijbiomac.2012.09.009
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center