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Food Chem Toxicol. 2013 Jan;51:46-52. doi: 10.1016/j.fct.2012.09.011. Epub 2012 Sep 19.

Low-dose gamma irradiation of food protein increases its allergenicity in a chronic oral challenge.

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Unidade Acadêmica de Medicina Veterinária, CSTR, Universidade Federal de Campina Grande, Patos, Paraíba, Brazil.


Few chronic food protein models have described the relationship between allergenicity and the molecular structure of food protein after physical processing. The effect of γ-radiation on the structure of food protein was measured by fluorescence, circular dichroism and microcalorimetry. BALB/c mice were intraperitoneally sensitized and then given non-irradiated and irradiated Con-A by daily gavage for 28days. The tendency to form insoluble amorphous aggregates and partially unfolded species was observed after irradiation. The administration of non-irradiated and irradiated samples at low-dose significantly increased weight loss as well as plasma levels of eotaxin in animals repeatedly exposed to Con-A. Significant lymphocytic infiltrate filling completely the stroma of microvilli and tubular glands was observed in the small intestinal of the group given Con-A irradiated at a low dose. This phenotype was not observed in animals treated with Con-A irradiated at a high dose.

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